The Yale Center for Molecular Discovery (YCMD) is happy to announce the continuation of its Nanocourse in Molecular Design and Screening. The course will be held on May 31 from 9am until 2pm at Yale West Campus.
The May course is fully enrolled and another is anticipated in late Summer or early Autumn.
The goal of this course is to provide an overview of strategies for assay design, optimization and screening of small molecules and/or siRNA libraries. High throughput and high content screening approaches as well as compound virtual screening and drug design will be highlighted. The format will heavily emphasize discussion of best practices based on actual projects. Three small group breakout sessions (8-10 person each) will provide real-world examples of past or ongoing projects.
The Nanocourse is available to all Yale students, staff and faculty. Attendance will be limited to 24 people and an application form can be found below. If the number of applicants greatly exceeds the limit, additional dates may be scheduled. Lunch will be provided.
Agenda:
General Introduction to Project Strategy (9-10am)
Goals of Nanocourse
YCMD Mission & Approach
Questions/Discussion
Breakout Sessions (10am – 1:30pm)
I. Biochemical Screening
Assay Design & Adaptation for Screening
Readout Options
II. Cell-Based Screening
Assay Design
High Content Screening vs. Plate-Based Readers
III.Chemical Lead Finding and Optimization
Ligand-Based Virtual Screening
Structure-Based Virtual Screening
Drug Design Considerations
YCMD New Initiatives & Wrap Up (1:30-2:00pm)