Who we are
The Center is staffed by a team of experienced biomedical scientists with experience in both academia
and the biopharmaceutical industry. Our diverse experiences provide unique insights to advance projects
through hurdles that sometimes limit applying promising academic research to fundamental challenges.
What we do
Our mission is to provide insight into biological mechanisms and disease targets. We provide expertise in
compound and siRNA screening, synthetic molecular design and high-content imaging. We work with you
to discover new chemical probes or biological functions to better understand disease or basic biochemical
mechanisms and provide new opportunities for drug development.
What you can expect
We are professional. We work with you to understand your needs and together identify milestones, timelines
and project costs to achieve success.
We are quantitative. We generate controlled numerical data, in replicate, to guide all phases of our work.
Signal, background and variability data drive decision making.
We are efficient. We can survey many assay conditions on a 384-well plate at once. We probe structural
features in your compound to find those that correlate with activity to suggest new molecules enriched for
these features. We synthesize small libraries of compounds when analoging, when feasible, to generate more
We are experienced. From a range of industry settings, our strategies are based on our experiences in applying
technology, medicinal chemistry and bioinformatics approaches to varied disease-based or biological research
We have useful tools and maintain them well. A good tool, correctly applied, simplifies a task. It saves reagents
and time, and reduces variability, error and injury.
What we can expect
Your needs are unique. You may have made your reagents and be the only person in the world with access and
experience using them. Your project may be like none we’ve seen before.
Your resources are limited. We assist in writing grant applications by providing grant text, letters of support,
biosketches, and other information as needed. We underwrite at least 50% of the costs of all activities performed
in the Center for the Yale community.