Your Research + YCMD Resources = New Molecules and Biological Insight     

Yale Center for Molecular Discovery (YCMD) is a full-service core facility specializing in high throughput assay development and screening of chemical and genomic probes. YCMD maintains and makes available for screening a diverse collection of drug-like small molecules, including targeted libraries of bioactive compounds for pilot and drug repurposing screening as well as >300,000 compounds in diversity collections for a large-scale, unbiased screening. YCMD also offers arrayed genomic libraries, including an arrayed sgRNA library which targets >19,000 human genes for CRISPR screening. YCMD maintains a sophisticated infrastructure, including cutting-edge screening instrumentation and analysis databases, to support high throughput assay design, screening, hit validation, and liquid handling and reformatting needs. The core facility is staffed with PhD and MS level scientists with unique and deep expertise in assay optimization, high throughput screening and medicinal chemistry hit-to-lead development approaches. Biology services include microplate-based biochemical, biophysical and cell-based screening with platereader, high content microscopy, and SPR-based readouts. Medicinal chemistry services include hit optimization, structure-activity relationship studies for lead development, and computational medicinal chemistry including docking, virtual screening, and structure-based drug design. The Center offers full-service support in developing and miniaturizing assays and executing robust screening and development pipelines. YCMD staff also provides expert consultations, helps assess feasibility and design assays amenable to screening, supports grant applications, and participates in numerous education and outreach efforts in the areas of therapeutic target validation and lead discovery.

Publication Acknowledgment

If research supported by this Research Core results in publication, please acknowledge this support by including the following in your publication(s): “We thank the Yale Center for Molecular Discovery for their assistance with ________ service. The Core is supported in part by an NCI Cancer Center Support Grant # NIH P30 CA016359.”

If ImageXpress Micro 4 was used to support your work, please include this statement under funding: “This work utilized ImageXpress Micro 4 high content imager that was purchased with funding from a National Institutes of Health SIG grant 1S10OD032384”. 

If Echo 650 acoustic dispenser was used to support your work, please include this statement under funding: “This work utilized Echo 650 Acoustic Liquid Handler that was purchased with funding from a National Institutes of Health SIG grant 1S10OD038347”.